Spatial learning with a minislab in the dorsal hippocampus.

AUTOR(ES)

Moser, M B

RESUMO

We have determined the volume and location of hippocampal tissue required for normal acquisition of a spatial memory task. Ibotenic acid was used to make bilateral symmetric lesions of 20-100% of hippocampal volume. Even a small transverse block (minislab) of the hippocampus (down to 26% of the total) could support spatial learning in a water maze, provided it was at the septal (dorsal) pole of the hippocampus. Lesions of the septal pole, leaving 60% of the hippocampi intact, caused a learning deficit, although normal electrophysiological responses, synaptic plasticity, and preserved acetylcholinesterase staining argue for adequate function of the remaining tissue. Thus, with an otherwise normal brain, hippocampal-dependent spatial learning only requires a minislab of dorsal hippocampal tissue.

Documentos Relacionados

• Associative learning potentiates protein kinase C activation in synaptosomes of the rabbit hippocampus.
• Preserved neuron number in the hippocampus of aged rats with spatial learning deficits.
• Hebbian synapses in hippocampus.
• Enkephalin hyperpolarizes interneurones in the rat hippocampus.
• Characterization of a uterine-type oxytocin receptor in the rat hippocampus.