Somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with Parkinson's disease and its relation to dementia.
AUTOR(ES)
Jolkkonen, J
RESUMO
Acetylcholinesterase, somatostatin-like immunoreactivity, and homovanillic acid levels were measured in the cerebrospinal fluid of 36 patients with early stages of Parkinson's disease and in 19 control patients. In patients with Parkinson's disease the levels of somatostatin-like immunoreactivity were lower than in the controls (p less than 0.01); these values were lowest in the demented Parkinsonian patients. Concentrations of homovanillic acid were also significantly lower in Parkinsonian patients (p less than 0.05). In contrast, no changes were observed in the acetylcholinesterase activity of patients with Parkinson's disease. The reduced somatostatin-like immunoreactivity in CSF agrees with previous post-mortem studies and indicates that Parkinson's disease and Alzheimer's disease may have some neurochemical features in common.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1029121Documentos Relacionados
- CSF somatostatin-like immunoreactivity in dementia of Parkinson's disease.
- Somatostatin-like immunoreactivity in the retina.
- Measurement, Characterization, and Source of Somatostatin-like Immunoreactivity in Human Amniotic Fluid
- Properties of endogenous somatostatin-like immunoreactivity and synthetic somatostatin in dog plasma.
- Contribution of the pancreas to circulating somatostatin-like immunoreactivity in the normal dog.
