Somatostatin content and receptors in the cerebral cortex of depressed and control subjects.

AUTOR(ES)

Charlton, B G

RESUMO

Somatostatin-like immunoreactivity is reduced in the cerebrospinal fluid in depression and this is presumed to reflect alterations in cerebral somatostatinergic systems. We have examined this hypothesis by measuring this immunoreactivity and somatostatin receptors in post-mortem cortical tissue from depressed patients and control subjects. There was no significant difference in the temporal and occipital cortex in somatostatin-like immunoreactivity or in somatostatin receptor affinity and binding capacity between depressed and control groups. It is concluded that there may not be an alteration of cortical somatostatin function in depression.

Documentos Relacionados

• Characterisation of messenger RNA extracted post-mortem from the brains of schizophrenic, depressed and control subjects.
• Studies of liver insulin receptors in non-obese and obese human subjects.
• Prostaglandins and the control of airways responses to histamine in normal and asthmatic subjects.
• Visual evoked potentials and pattern electroretinograms in Parkinson's disease and control subjects.
• Alpha-1-antitrypsin content in the serum, alveolar macrophages, and alveolar lavage fluid of smoking and nonsmoking normal subjects.