Sodium polyanethol sulfonate inactivation of aminoglycosides.

AUTOR(ES)

Krogstad, D J

RESUMO

Sodium polyanethol sulfonate and another polyanion (dextran sulfate) both inhibited aminoglycoside activity in vitro. This effect was not produced by an otherwise similar neutral carbohydrate (dextran) or by neutral detergents (Brij-35, Triton X-100) but was antagonized by an anion-exchange resin (Dowex 1X8-50). We conclude that the inactivation of aminoglycosides by sodium polyanethol sulfonate results from its polyanionic nature and is unrelated to its detergent properties.

Documentos Relacionados

• Sodium Polyanethol Sulfonate Sensitivity of Anaerobic Cocci
• Effect of sodium polyanethol sulfonate in blood cultures.
• Neutralization of human serum lysozyme by sodium polyanethol sulfonate but not by sodium amylosulfate.
• Detection of Bacteremia in Children with Sodium Polyanethol Sulfonate: a Prospective Clinical Study
• Use of Sodium Polyanethol Sulfonate in the Preparation of 5% Sheep Blood Agar Plates