Sodium alendronate dental adsortion analysis through high performance liquid cromatography, considering the topical use before delayed replantation / Análise da absorção dental do alendronato de sódio através da cromatografia líquida de alta eficiência visando a utilização tópica antes do reimplante tardio

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Delayed tooth replantation is considered a poor prognosis because of ankylosis and root resorption occurrence. The use of drugs for topical treatment before replantation is recommended expecting better prognosis. Recently, the sodium alendronate has been experimentally indicated for this purpose; but tooth adsorption capability of this drug is unknown. The aim of this study was to evaluate the tooth adsorption of sodium alendronate utilizing the High Performance Liquid Chromatography. Six maxillary central incisors were immersed in solutions of alendronate in concentrations of 10-5 and 10-4M; after experimental times of 10, 15 e 30 minutes samples of solutions were obtained for concentration analysis. The concentrations obtained were compared with control concentrations (solutions without tooth immersion). The results showed the occurrence of adsorption when teeth were immersed in sodium alendronate solutions. At the concentration of 10-5M it is necessary to keep the tooth immersed for at least 15 minutes, while at the concentration of 10-4M after 10 minutes a high adsorption value is observed.

ASSUNTO(S)

avulsão resorptions sodium alendronate avulsion dental trauma traumatismo dental reimplante tardio delayed replantation alendronato de sódio reabsorções

ACESSO AO ARTIGO

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