small ORFs: A new class of essential genes for development
AUTOR(ES)
Albuquerque, João Paulo, Tobias-Santos, Vitória, Rodrigues, Aline Cáceres, Mury, Flávia Borges, Fonseca, Rodrigo Nunes da
FONTE
Genet. Mol. Biol.
DATA DE PUBLICAÇÃO
2015-09
RESUMO
Genes that contain small open reading frames (smORFs) constitute a new group of eukaryotic genes and are expected to represent 5% of the Drosophila melanogaster transcribed genes. In this review we provide a historical perspective of their recent discovery, describe their general mechanism and discuss the importance of smORFs for future genomic and transcriptomic studies. Finally, we discuss the biological role of the most studied smORF so far, the Mlpt/Pri/Tal gene in arthropods. The pleiotropic action of Mlpt/Pri/Tal in D. melanogaster suggests a complex evolutionary scenario that can be used to understand the origins, evolution and integration of smORFs into complex gene regulatory networks.
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