Small fragments of herpesvirus DNA with transforming activity contain insertion sequence-like structures.
AUTOR(ES)
Galloway, D A
RESUMO
A 737-base-pair fragment of herpes simplex virus type 2 DNA with morphological-transforming ability was identified by transfecting into rodent cells deleted fragments of the left-hand end of the Bgl II N fragment region (map position 0.58-0.625), which were constructed in vitro. The transforming sequences lie within the coding region for a Mr 61,000 protein, but the fragment itself does not appear to specify a viral polypeptide. Contained within the transforming fragment are sequences that can be drawn as a stem-loop structure flanked by direct repeats, similar to an insertion sequence-like element. An insertion sequence-like structure was also found in a small fragment of human cytomegalovirus DNA that has transforming activity. Possible mechanisms of herpesvirus transformation are discussed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=391565Documentos Relacionados
- Characterization of Porphyromonas gingivalis Insertion Sequence-Like Element ISPg5
- Characterization of IS1272, an insertion sequence-like element from Staphylococcus haemolyticus.
- IS195, an Insertion Sequence-Like Element Associated with Protease Genes in Porphyromonas gingivalis
- Identification of an insertion sequence-like element in a subspecies of Mycobacterium kansasii.
- Tandem insertion sequence-like elements define the expression site for variable antigen genes of Borrelia hermsii.
