Slowing effects of dopamine and calcium-channel blockers on frequency of sodium spikes in rat pars intermedia cells

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RESUMO

1. Spontaneous discharge of action potentials (Na spikes) in cells isolated from rat pars intermedia was slowed or arrested by Co2+, Ni2+ or Mn2+, which block voltage-dependent Ca channels in these cells. The amplitude of persisting spikes was undiminished. The effects resembled those of dopamine.

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