Slow clearance of Plasmodium vivax with chloroquine amongst children younger than six months of age in the Brazilian Amazon
AUTOR(ES)
Siqueira, André M, Coutinho, Lucas I, Gurgel, Rafael L, Su, Willian CS, Carvalho, Luiz M, Benzecry, Silvana G, Alencar, Aline CC, Alexandre, Márcia AA, Alecrim, Maria Graças C, Lacerda, Marcus VG
FONTE
Mem. Inst. Oswaldo Cruz
DATA DE PUBLICAÇÃO
05/08/2014
RESUMO
Plasmodium vivax is the most widespread parasite causing malaria, being especially prevalent in the Americas and Southeast Asia. Children are one of the most affected populations, especially in highly endemic areas. However, there are few studies evaluating the therapeutic response of infants with vivax malaria. This study retrospectively evaluated the parasitaemia clearance in children diagnosed with vivax malaria during the first five days of exclusive treatment with chloroquine (CQ). Infants aged less than six months old had a significantly slower parasitaemia clearance time compared to the group of infants and children between six months and 12 years old (Kaplan-Meier survival analysis; Wilcoxon test; p = 0.004). The impaired clearance of parasitaemia in younger children with vivax malaria is shown for the first time in Latin America. It is speculated that CQ pharmacokinetics in young children with vivax malaria is distinct, but this specific population may also allow the detection of CQ-resistant parasites during follow-up, due to the lack of previous immunity.
Documentos Relacionados
- Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
- Chloroquine Resistance in Plasmodium vivax
- Asymptomatic infection with Plasmodium falciparum and Plasmodium vivax in the Brazilian Amazon Basin: to treat or not to treat?
- Chloroquine and mefloquine resistance profiles are not related to the circumsporozoite protein (CSP) VK210 subtypes in field isolates of Plasmodium vivax from Manaus, Brazilian Amazon
- Follow-up after infants younger than 2 months of age with urinary tract infection in Southern Israel: epidemiologic, microbiologic and disease recurrence characteristics