Sizing up the nucleus: nuclear shape, size and nuclear-envelope assembly

AUTOR(ES)

Webster, Micah

FONTE

Company of Biologists

RESUMO

The nucleus is one of the most prominent cellular organelles, yet surprisingly little is known about how it is formed, what determines its shape and what defines its size. As the nuclear envelope (NE) disassembles in each and every cell cycle in metazoans, the process of rebuilding the nucleus is crucial for proper development and cell proliferation. In this Commentary, we summarize what is known about the regulation of nuclear shape and size, and highlight recent findings that shed light on the process of building a nucleus, including new discoveries related to NE assembly and the relationship between the NE and the endoplasmic reticulum (ER). Throughout our discussion, we note interesting aspects of nuclear structure that have yet to be resolved. Finally, we present an idea – which we refer to as `the limited flat membrane hypothesis' – to explain the formation of a single nucleus that encompasses of all of the cell's chromosomes following mitosis.

Documentos Relacionados

• Size, shape, and the thermal niche of endotherms
• In vivo assembly of a biological membrane of defined size, shape, and lipid composition.
• Homozygous Defects in LMNA, Encoding Lamin A/C Nuclear-Envelope Proteins, Cause Autosomal Recessive Axonal Neuropathy in Human (Charcot-Marie-Tooth Disorder Type 2) and Mouse
• The effect of cultivation on the size, shape, and persistence of disease patches in fields
• A Quantitative Comparison Between Size, Shape, Topology and Simultaneous Optimization for Truss Structures