Sintese e caracterização do Poli(L-acido lactico)- PLLA e Poli(L-acido lactico-co- acido glicolico)- PLGA e estudo da degradação "in vitro"

AUTOR(ES)

Adriana Cristina Motta

DATA DE PUBLICAÇÃO

2002

RESUMO

The study and application of bioreabsorbable polyesters to repair damaged tissue is &very promising research area. Poly (L-lactic acid), PLLA, and Poly (lactic acid-co-glicolic acid), PLGA, are the most important bioreabsorbable polyesters due to their excellent biocompatibility and mechanical properties. In this work PLLA and PLGA were synthesized and characterized, and in vitro degradation of membranes was evaluated. The polymers were synthesized by ring opening of the cyclic diester of lactic acid, lactide, and g!icolic acid, glicolide using Sn(Octh catalyst. PLLA and PLGA polymers presented high values of molar mass (Mw around 105 g/mol) and their chemical structures were confirmed by IH and 13C NMR and IV. PLLA and PLGA thermal properties were studied by DSC and TGA, being verified that the homopolimer has a high crystallinity and copolymer has a low crystallinity. 1n vitro degradation study confirmed that the degradation process of PLGA membranes is faster than PLLA ones. This study showed that the synthesis of PLLA and PLGA costs can be decreased for 4-5 times compared to imported materials

ASSUNTO(S)

polimeros - deterioração materiais biomedicos poliesteres - sintese

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