Síntese e caracterização de nanoestruturas peptídicas: estudos espectroscópicos e aplicações / Synthesis and characterization of peptide nanostructures: spectroscopic studies and applications

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

27/02/2012

RESUMO

The study had as aimed the development of nanostructured materials based on processes of molecular self-assembly of peptide compounds in order to obtain systems of great structural versatility seeking possible applications related to bionanotechnology. In this regard, peptide sequences based on linear and cyclic precursors were synthesized by solid-phase method in strategy t-Boc and F-moc, respectively. Thus, the nanostructures were prepared by self-assembly process via solid-vapor phase, through variation of solvent (aniline, water and dichloromethane), concentration (50, 100 and 150 mg mL-1) and exposure time vapor (12 and 18 hours). The nanostructured materials were characterized by SEM, FTIR and TGA in order to investigate their morphological, structural and thermal. The experimental results presented nanoribbons to obtain a concentration of 150 mg mL-1 and time of exposure to vapor of 18 hours, showed that similar structures for all systems studied, as evidenced by infrared spectroscopy and molecular dynamics. Furthermore, it was possible to perform the electropolymerization of residual aniline, observed redox processes characteristic of polyaniline (PANI). Finally, we have prepared arrays poly(ɛ-caprolactone) with L-diphenylalanine nanotubes (NT-FF) by electrospinning, in order to study the changes in the thermal and mechanical properties of the nanocomposites which showed variation in the crystallinity and elastic-plastic deformation.

ASSUNTO(S)

nanoestruturas peptídicas materiais biológicos sistemas supramoleculares automontagem eletrofiação peptide nanostructures biological materials supramolecular systems self-assembly electrospinning outros

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