SÍNTESE E CARACTERIZAÇÃO DE COMPOSTOS RESULTANTES DA INTERAÇÃO DE CISPLATINA COM ÁCIDO GUANIDOACÉTICO E ARGININA / SYNTHESIS AND CHARACTERIZATION OF RESULTANT COMPOUNDS FROM THE INTERACTION OF CISPLATINUM WITH GUANIDINOACETIC ACID AND ARGININE

AUTOR(ES)

LUCIANA DORNELAS PINTO

DATA DE PUBLICAÇÃO

2006

RESUMO

The aim of this work is the study of the interactions between cis-platinum, which is employed as a chemotherapic drug, and two amino acids of biological importance: guanidinoacetic acid (Gaa) and arginine (Arg). In order to work in conditions as similar as possible of the biological environment, this work was done in vitro, using only deionized water as a solvent. With this purpose, several synthesis procedures were tested which resulted in four different compounds: two with Gaa and two with arginine. These compounds were characterized through the following techniques: elementary analysis (atomic absorption spectrometry and CHN), conductimetry, thermogravimetric analysis, nuclear magnetic resonance, powder diffraction and infrared spectroscopy. It was possible to verify that both Gaa and arginine behaved as monodentates ligands and complexed with the cis-platinum through the amine´s nitrogen atom.

ASSUNTO(S)

arginine complexes arginina guanidinoacetic acid complexos cisplatin cisplatina acido guanidoacetico

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