SÍNTESE DE 4-(FUR-2-IL)- E 4-(TIEN-2-IL)-PIRIMIDINAS A PARTIR DE β-ALCOXIVINIL TRIFLUORMETIL CETONAS / SYNTHESIS OF 4-(FUR-2-YL)- AND 4-(THIEN-2-YL)-PYRIMIDINES FROM β-ALKOXYVINYL TRIFLUOROMETHYL KETONES

AUTOR(ES)

Lucas Pizzuti

DATA DE PUBLICAÇÃO

2005

RESUMO

The cyclocondensation of the 1,1,1-trifluoro-4-methoxy-4-(2-heteroaryl)-3-buten-2-ones (heteroaryl = furyl and thienyl) with urea and amidines (acetamidine, benzamidine, guanidine, 1H-pyrazole-1-carboxamidine and 2-methyl-2-thiopseudourea) for synthesis of two 4-(2-heteroaryl)-6-trifluoromethylpyrimidinones and a series of ten 4-(2-heteroaryl)-6-trifluoromethylpyrimidines is reported. The reaction of the 1,1,1-trifluoro-4-methoxy-4-(2-heteroaryl)-3-buten-2-ones with urea was carried out in the presence of boron trifluoride etherate as a catalyst, at 50C for 20 hours. The reactions of the same substracts with amidines were carried out in the presence of a 1 M solution of sodium hydroxide at r.t.-50C for 1 hour. Under this conditions, only aromatic pyrimidines were obtained in 48-67%.

ASSUNTO(S)

pirimidinas sintese quimica quimica quimica

Documentos Relacionados

• REGIOSPECIFIC SYNTHESIS OF β-ALKOXYVINYL TRIHALOMETHYL KETONES WITH HETEROAROYLHYDRAZINES
• β-Alkoxyvinyl Halomethyl Ketones: Synthesis and application in obtaining of haloaryl enaminones, bis-haloarylenaminones, and 5-dichloromethyl-3-methyl-1H-pyrazoles.
• SYNTHESIS OF 1,2,4-TRIAZOL-5-YLAMINO PYRIMIDINES TRIFLUOROMETHYL SUBSTITUTED
• Synthesis of 6-methylsubstituted 2-phenyl-3H-pyrimidin-4-ones and 4-trifluoromethyl-2-ureido pyrimidines
• SULFOXIMIDOVINIL TRIFLUORMETIL CETONAS. OBTENÇÃO E APLICAÇÃO NA SÍNTESE DE AZÓIS E AZINAS DERIVADAS