Single-dose pharmacokinetics of cefsulodin in patients with cystic fibrosis.
AUTOR(ES)
Reed, M D
RESUMO
The single-dose pharmacokinetics of cefsulodin were evaluated in 12 patients with cystic fibrosis. Each patient received 3 g of cefsulodin intravenously over 30 min. Multiple plasma and urine samples were obtained during the 6-h study period for the determination of cefsulodin. Pharmacokinetic parameters were determined by model-independent methods. Mean values for t1/2, Vss, and CLp were 1.53 h, 0.242 liters/kg, and 117.3 ml/min per 1.73 m2, respectively. Six-hour urine recovery revealed 73.2% of the administered dose with a corresponding cefsulodin urinary clearance of 75.1 ml/min. These pharmacokinetic data in patients with cystic fibrosis appear consistent with data reported for unaffected individuals.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=185590Documentos Relacionados
- Single-dose pharmacokinetics of aztreonam in pediatric patients.
- Single-dose pharmacokinetics of oral fleroxacin in bacteremic patients.
- Single-dose pharmacokinetics of acyclovir.
- Single-dose pharmacokinetics of intravenous clavulanic acid with amoxicillin in pediatric patients.
- Single-dose pharmacokinetics of thalidomide in human immunodeficiency virus-infected patients.