Single-Dose Doxycycline for Cholera
AUTOR(ES)
Sack, David A.
RESUMO
To determine the efficacy of single-dose doxycycline in the treatment of cholera, we carried out a randomized prospective trial in 65 patients. Treatment consisted of either a single dose of 200 mg of doxycycline (or 4 mg/kg in patients less than 15 years old) or multiple doses of doxycycline, 500 mg over 4 days (or 10 mg/kg in patients less than 15 years old). There were no differences between the groups in the volumes of intravenous fluid required, volumes of diarrheal stool, or durations of diarrhea. The mean duration of positive stool cultures for Vibrio cholerae was similar for the two groups, although in both groups several patients continued to excrete Vibrios in the stool for more than 3 days. Blood levels of antibiotic demonstrated that the doxycycline was absorbed in spite of the rapid transit time associated with severe diarrhea. These results suggest that although tetracycline remains the drug of choice for cholera, doxycycline is a reasonable alternative, and that a single dose of 200 mg (4 mg/kg in children) is effective clinically.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=352482Documentos Relacionados
- Single-dose ceftriaxone for chancroid.
- Doxycycline in the single-dose treatment of gonorrhoea. Effect on Treponema pallidum.
- Doxycycline HC1 (Vibramycin) syrup as a single-dose oral treatment for uncomplicated urethritis in men.
- Single-dose pharmacokinetics of acyclovir.
- Single-dose tinidazole for the treatment of giardiasis.