Simple and sensitive spectrophotometric methods for the analysis of mesalamine in bulk and tablet dosage forms

AUTOR(ES)

Chandra, Bala Sekaran, Bhogela, Siva Santhosh, Shaik, Manjusha, Vadlamudi, Chaitanya Sravanthi, Chappa, Meghana, Maddirala, Naga Sirisha

FONTE

Química Nova

DATA DE PUBLICAÇÃO

2011

RESUMO

Three simple, sensitive, economical and reproducible spectrophotometric methods (A, B and C) are described for determination of mesalamine in pure drug as well as in tablet dosage forms. Method A is based on the reduction of tungstate and/or molybdate in Folin Ciocalteu's reagent; method B describes the reaction between the diazotized drug and α-naphthol and method C is based on the reaction of the drug with vanillin, in acidic medium. Under optimum conditions, mesalamine could be quantified in the concentration ranges, 1-30, 1-15 and 2-30 µg mL-1 by method A, B and C, respectively. All the methods have been applied to the determination of mesalamine in tablet dosage forms. Results of analysis are validated statistically.

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