Silica exposure, silicosis, and lung cancer: a mortality study of South African gold miners.
AUTOR(ES)
Hnizdo, E
RESUMO
The effects of exposure to gold mining dust with a high concentration of free silica and tobacco smoking on mortality from lung cancer was assessed in a sample of 2209 white South African gold miners who started mining exposure during 1936-43, and were selected for a study of respiratory disorders in 1968-71 when they were aged 45-54. The mortality follow up was from 1968-71 to 30 December 1986. The relative risk for the effect of dust cumulated to the start of the follow up period was estimated as 1.023 (95% confidence interval (CI) 1.005-1.042) for a unit of 1000 particle-years. The combined effect of dust and tobacco smoking was better fitted by the multiplicative model than the additive model, suggesting that the two exposures act synergistically. No association between lung cancer and silicosis of the parenchyma or pleura was found, but a positive association existed between silicosis of the hilar glands and lung cancer.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1035313Documentos Relacionados
- Silica exposure, silicosis, and lung cancer: a necropsy study.
- Association of silicosis, lung dysfunction, and emphysema in gold miners.
- Mortality of white South African gold miners.
- Mortality of middle aged white South African gold miners.
- Loss of lung function associated with exposure to silica dust and with smoking and its relation to disability and mortality in South African gold miners.