sICAM-1 in meningoencephalitis due to Angiostrongylus cantonensis

AUTOR(ES)

Dorta-Contreras, Alberto Juan, Lewczuc, Piotr, Noris-García, Elena, Interián-Morales, María Teresa, Magraner Tarrau, María Esther, Padilla-Docal, Bárbara, Escobar-Pérez, Xiomara

FONTE

Arquivos de Neuro-Psiquiatria

DATA DE PUBLICAÇÃO

2006-09

RESUMO

INTRODUCTION: Angiostrongylus cantonensis meningoencephalitis is an emergent disease in the Americas. METHOD: Twelve children suffering from eosinophilic meningoencephalitis due to this parasite aged between 6-10 years were studied. Cerebrospinal fluid (CSF) and serum samples were taken simultaneously in the first diagnostic puncture at admission. RESULTS: All cases showed typical findings on the routine CSF and serum analysis: increased CSF total protein, increased Q (CSF/serum) albumin accompanied by eosinophilia in CSF. No intrathecal synthesis of immunoglobulins was found. Mean serum and CSF sICAM-1 values were 337.4 and 3.97 ng/mL. Qalbumin and QsICAM-1 mean values were 4.1 and 6.2 respectively. In 50% of the patients an increased brain-derived fraction of sICAM-1 was found. CONCLUSION: It may be suggested that a dynamic of the sICAM-1 brain derived fraction is perhaps associated to the immune response in the evolution of the disease.sICAM-1 may be an agent in negative feedback for eosinophils passage through the blood-CSF barrier into the inflammatory brain response.

Documentos Relacionados

• sICAM-1 intrathecal synthesis and release during the acute phase in children suffering from Coxsackie A9 and S. pneumoniae meningoencephalitis
• Intrathecal Synthesis of Immunoglobulins in Eosinophilic Meningoencephalitis Due to Angiostrongylus cantonensis
• Levels of CXCL13 and sICAM-1 correlate with disease activity score in patients with rheumatoid arthritis treated with tocilizumab
• Eosinophilic meningitis due to Angiostrongylus cantonensis.
• Comparative antirhinoviral activities of soluble intercellular adhesion molecule-1 (sICAM-1) and chimeric ICAM-1/immunoglobulin A molecule.