Severe anemia affects both splenectomized and non-splenectomized Plasmodium falciparum-infected Aotus infulatus monkeys

AUTOR(ES)

Carvalho, Leonardo J de Moura, Alves, Francisco Acácio, Oliveira, Salma Gomes de, Rio do Valle, Rodrigo del, Fernandes, Andréa A Morais, Muniz, José A Pereira Carneiro, Daniel-Ribeiro, Claudio T

FONTE

Memórias do Instituto Oswaldo Cruz

DATA DE PUBLICAÇÃO

2003-07

RESUMO

Severe anemia is the earliest and a frequently fatal complication of Plasmodium falciparum infection. Here we describe Aotus infulatus as a primate model suitable to study this malaria complication. Both non-splenectomized and splenectomized monkeys receiving different inocula of P. falciparum FVO strain presented large (> 50%) decreases in hematocrit values during infection. Non-splenectomized animals were able to control parasite growth (parasitemia did not exceed 4%), but they had to be treated because of severe anemia. Three of 4 splenectomized monkeys did not control parasitemia and were treated, but developed severe anemia after treatment when presenting a negative blood film. Destruction of parasitized red blood cells alone cannot account for the degree of anemia. Non-splenectomized monkeys repeatedly infected with homologous parasites became rapidly and progressively resistant to reinfection and to the development of severe anemia. The data presented here point to A. infulatus as a suitable model for studying the pathogenesis of severe malarial infection.

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