Níveis séricos da proteína carreadora do retinol 4 e risco cardiovascular no diabetes mellitus tipo 2 / Serum levels of retinol-binding protein 4 and cardiovascular risk in type 2 diabetes mellitus

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

23/10/2012

RESUMO

Objectives: to evaluate the levels of serum RBP4 in premenopausal obese diabetic patients compared with nondiabetic patients. To evaluate the correlation between serum RBP4 with well-established markers of IR and MS. Compare between groups the percentage of body fat (% BF) and thickness of carotid intima-media (CIMT), checking the influence of T2DM into groups. Methods: We evaluated 139 women which were divided into 3 groups: Group 1 (Control, n = 45), Group 2 (obese, n = 53) and group 3 (obese T2DM, n = 41), known as G1, G2 and G3. We assessed biochemical, anthropometric and body composition parameters. Results: There was no statistically significant difference between groups in the parameters for sample characterization regarding the expected profiles of metabolic syndrome, type 2 diabetes and obesity. However, RBP4 levels did not behave as expected when compared to the first studies about the retinol-binding protein. Conclusions: The RPB4 is not a good marker of IR and cardiovascular risk, because distribution between the groups was not uniform. According to data analysis, we obtained in G1 positive correlations of RBP4 with BMI (p <0.05), and glycated hemoglobin (p <0.05), fasting insulin (p <0.05); in G2 with glycated hemoglobin (p <0.01); G3 with glycated hemoglobin (p <0.05), fasting glucose (p <0.01), HOMA-IR (p <0.01)

ASSUNTO(S)

obesidade sindrome x metabolica resistência à insulina mulheres pré-menopausa obesity metabolic syndrome x insulin resistance women premenopause

ACESSO AO ARTIGO

Documentos Relacionados