Seroprevalence of hepatitis E virus in chronic hepatitis C in Brazil

AUTOR(ES)

Bricks, Guilherme, Senise, Jorge Figueiredo, Pott Junior, Henrique, Grandi, Giuliano, Passarini, Amanda, Caldeira, Débora Bellini, Carnaúba Junior, Dimas, Moraes, Hamilton Antonio Bonilha de, Granato, Celso Franscisco Hernandes, Castelo, Adauto

FONTE

Braz J Infect Dis

DATA DE PUBLICAÇÃO

2018-03

RESUMO

ABSTRACT Background and aims: Hepatitis E virus infection in patients with underlying chronic liver disease is associated with liver decompensation and increased lethality. The seroprevalence of hepatitis E virus in patients with chronic hepatitis C in Brazil is unknown. This study aims to estimate the seroprevalence of hepatitis E virus in patients with chronic hepatitis C and to describe associated risk factors. Methods: A total of 618 patients chronically infected with hepatitis C virus from three reference centers of São Paulo, Brazil were included. Presence of anti-HEV IgG was assessed by enzyme-linked immunosorbent assay (WANTAI HEV-IgG ELISA). Results: Out of the 618 patients tested, 10.2% turned out positive for anti-HEV IgG (95% CI 8.0–12.8%). Higher seroprevalence was found independently associated with age over 60 years (OR = 2.04; p = 0.02) and previous contact with pigs (OR = 1.99; p = 0.03). Conclusions: Patients with chronic hepatitis C are under risk of hepatitis E virus superinfection in São Paulo. Contact with pigs is a risk factor for the infection, suggesting a possible zoonosis with oral transmission.

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