"Sequenciamento da região NS5A do genoma do vírus da hepatite C, genótipo 3, de pacientes brasileiros com infecção crônica" / Sequencing of NS5A region of HCV genotype 3 in brazilian patienwith chronic disease

AUTOR(ES)

Fernanda de Mello Malta

DATA DE PUBLICAÇÃO

2006

RESUMO

The aim of this study was to analyse the sequences of fragments of E2 and NS5A regions from 33 outpatients infected with HCV genotype 3, including cirrhotic (C) and non-cirrhotic (NC) patients that have responded (R) or not (NR) to treatment. In the E2 region, we did observe few amino acids changes between patients without statistical significance. In the NLS region and in V3 domain, we found conservatives mutations with statistical significance. In conclusion, our results confirm that the ISDR domain is not predictive for treatment success in patients infected with HCV genotype 3. The carboxy-terminal region and especifically V3 domain region showed most of variations. Structure-function studies are required to identify precisely how NS5A and IFN interact

ASSUNTO(S)

genotype interferon alfa análise mutacional do dna dna mutational analyses genótipo ief-2 kinase eif-2 kinase hepatite c crônica proteínas não estruturais virais chronic hepatitis c viral nonstrutural proteins interferon-alpha

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