Sequence analysis of mouse vomeronasal receptor gene clusters reveals common promoter motifs and a history of recent expansion
AUTOR(ES)
Lane, Robert P.
FONTE
The National Academy of Sciences
RESUMO
We have analyzed the organization and sequence of 73 V1R genes encoding putative pheromone receptors to identify regulatory features and characterize the evolutionary history of the V1R family. The 73 V1Rs arose from seven ancestral genes around the time of mouse–rat speciation through large local duplications, and this expansion may contribute to speciation events. Orthologous V1R genes appear to have been lost during primate evolution. Exceptional noncoding homology is observed across four V1R subfamilies at one cluster and thus may be important for locus-specific transcriptional regulation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=117554Documentos Relacionados
- Genomic structure analysis of promoter sequence of a mouse mu opioid receptor gene.
- Comparative DNA Sequence Analysis of Mouse and Human Protocadherin Gene Clusters
- Sequence Diversity and Genomic Organization of Vomeronasal Receptor Genes in the Mouse
- Differential Expansion of Zinc-Finger Transcription Factor Loci in Homologous Human and Mouse Gene Clusters
- Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse β-globin gene clusters