Sepse e choque septico em crianças em Unidade de Terapia Intensiva : epidemiologia e fatores de risco para obito




This study has started because of the frequent presence of sepsis in the Pediatric Intensive Care Unit (PICU), its aggressive treatment and the high death levels involved. The objective of the study was to describe the sepsis in children from the PICU, analyzing their epidemiological, clinical and laboratorial profile in the moment of admission and their following up. The study was based in the analysis of the charts from Clinical Hospital of Universidade Estadual de Campinas? PICU patients admitted from January, 1996 until December, 2000. All the chosen patients had sepsis, systemic inflammatory response syndrome or septic shock as the admission diagnosis hypothesis. The patients? data were analyzed based on a card, which had epidemiological, clinical and laboratorial parameters from the first 24 hours of the admission, as well as the following up and the evolution to discharge or death. A statistical analysis of logistic regression was performed based on epidemiological, clinical and laboratorial parameters. The results have shown that the majority of the admitted children was infant, healthy, came of domiciliary, and had already had previous treatments, such as antibiotic therapies and intubations. The most frequent symptoms and signs were fever, dispnea, diarrhea and altered mental status. The majority of the pacients needed antibiotic therapy, mechanical ventilation and central venous access as soon as they were admitted in the PICU. The bacterial etiologies were identified in 32% of the patients. The univariate logistic regression analysis has identified the following death risk factors: the not-domiciliary origin of the sepsis, underlying disease, aspect of the shock, the presence of hypotension, altered mental status, thrombocytopenia, hypoxemia and hyperlactatemia. The multivariate analysis has identified the following independent death risk factors: thrombocytopenia, underlying disease and aspect of the shock. The rate of mortality was 39%, and 41,9% of them had less 48 hours of admission. The mortality stays high and patients are still admitted on severe illness. Risk factors to poor prognosis are depending on the severity of individual instance of illness (thrombocytopenia, hypotension, hypoxemia, aspect of the shock) and presence of underlying disease


mortalidade infantil unidade de tratamento intensivo septicemia nas crianças infecção em crianças

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