Separation of l-tryptophan present in an aromatic amino acids mixture in a four-column simulated moving bed: experimental and simulation studies

AUTOR(ES)

Cremasco, M. A., Starquit, A., Wang, N.-H. L.

FONTE

Brazilian Journal of Chemical Engineering

DATA DE PUBLICAÇÃO

2009-09

RESUMO

An experimental and theoretical study is presented for the fractionation of L-Tryptophan (Trp) from L-phenylalanine (Phe) and L-tyrosine (Tyr). A Simulated-Moving Bed (SMB) with four-column system was tested, and the results are presented as effluent histories of the raffinate and extract ports. L-phenylalanine and L-tyrosine were recovered as major products in the raffinate, while L-Tryptophan was recovered at the extract. To simulate the L-Tryptophan separation, a general rate model was used to represent the mass transfer phenomena that occur in each individual column of the SMB, for each solute present in the multicomponent system. A hybrid method was used to solve the model. An analytic solution was used for the intra-particle concentration, and was correlated to the liquid bed concentration by Duhamel's theorem. The results from simulation are compared with the experimental data presented in this work.

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