Sensibilidade diferencial aos efeitos comportamentais induzidos por etanol e sobre a expressão de c-Fos e Egr-1, entre camundongos adultos e adolescentes. / Differential sensitivity to ethanol-induced behavioral effects and c-Fos /Egr-1 expression between adolescent and adult mice.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

The transition from adolescence (ADOLESC) into adulthood (ADULT) is characterized by behavioral maturation, as well as of structures and systems of CNS. This study investigated the behavioral effects of acute and repeated administration of EtOH (2,0 g/kg) in ADULT and ADOLESC mice, as well as the c-Fos and Egr-1 expression induced by EtOH in distinctive brain structures. Locomotor activity from ADULT and ADOLESC mice acutely treated with either saline (SAL) or EtOH was measured in open field (OF). One hour after injections, c-Fos and Egr-1 expressions were evaluated by immunohistochemistry. The results demonstrated increased locomotor activity and increased c-Fos and Egr-1 expression in EtOH-treated mice. Other groups of ADULT and ADOLESC mice were treated repeatedly with SAL or EtOH during 15 days. One week after this pretreatment, all animals received an injection of EtOH. The locomotor activity was quantified and c-Fos and Egr-1 expressions were evaluated. While ADULT mice presented behavioral sensitization, ADOLESC mice developed tolerance. The repeated administration of EtOH induced an age-dependent differential expression of c-Fos and Egr-1 in several brain regions.

ASSUNTO(S)

comportamento nuclear protein adolescentes adolescents behavior sistema límbico. limbic system. proteínas nucleares genes fos fos gene ethanol etanol

ACESSO AO ARTIGO

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