Selective decontamination of the digestive tract reduces mortality in critically ill patients
AUTOR(ES)
Schultz, Marcus J
FONTE
BioMed Central
RESUMO
Several emotional responses may be invoked in critical care physicians when confronted with selective decontamination of the digestive tract (SDD). Although recent meta-analyses have shown that the use of SDD reduces the occurrence of ventilator-associated pneumonia and improves ICU survival, the effectiveness of SDD has remained controversial. We recently concluded a large randomized, controlled trial on the use of SDD that showed improved survival of ICU patients treated with SDD. A second concern regarding use of SDD has been the fear for the emergence of antimicrobial resistance. Interestingly, a recently published study did not confirm this fear, and our recently finished study even demonstrated a decline in colonization with P. aeruginosa and enterobacteriaceae that were resistant against tobramycin, ceftazidime, imipenem and ciprofloxacin. The hopes are that this study will at long last end the debate about the efficacy and safety of SDD in critically ill patients.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=270619Documentos Relacionados
- Selective decontamination of the digestive tract by pipemidic acid.
- Selective decontamination of the digestive tract: all questions answered?
- Bacteriological aspects of selective decontamination of the digestive tract as a method of infection prevention in granulocytopenic patients.
- Excess mortality after human albumin administration in critically ill patients
- Opinion: The clinical use of selective digestive decontamination