Selection in Finite Populations. III. an Experimental Examination

AUTOR(ES)

Hedrick, Philip W.

RESUMO

The theory determining the probability of fixation of new mutants in a population that allows increased adaptation has been developed by Kimura. Two experimental systems were used to examine this theory. First, alleles were introduced at low frequencies into populations and their fate observed. The second approach was to follow populations with closely linked mutants that were introduced on different chromosomes and to follow the fate of favorable recombinants. These experiments allowed the investigation of the appropriateness of the mathematical model for the particular biological system. In the experiments reported here using two X-linked Drosophila mutants, y and w, the predictions of the theory were reasonably fulfilled in the first experimental system (introduction of new alleles), but not in the second system (favorable recombinants). However, the theoretical framework seems quite robust in that it allowed a satisfactory explanation of the experimental results for the second system as well. The probability of, and the time until, production of a favorable recombinant is discussed.

Documentos Relacionados

• Selection in Finite Populations with Multiple Alleles. III. Genetic Divergence with Centripetal Selection and Mutation
• Transposable Elements in Mendelian Populations. III. Statistical Results
• Selection in Experimental Populations. I. Lethal Genes
• Permanency of response to selection for quantitative characters in finite populations.
• On the Theory of Partially Inbreeding Finite Populations. III. Fixation Probabilities under Partial Selfing When Heterozygotes Are Intermediate in Viability