Secreted Effector Proteins of Salmonella enterica Serotype Typhimurium Elicit Host-Specific Chemokine Profiles in Animal Models of Typhoid Fever and Enterocolitis

AUTOR(ES)

Zhang, Shuping

FONTE

American Society for Microbiology

RESUMO

Infection of bovine ligated loops with the Salmonella enterica serotype Typhimurium wild type but not a sipA sopABDE2 mutant resulted in fluid accumulation, polymorphonuclear cell infiltration, and expression of CXC chemokines, particularly GROα. None of these sipA sopABDE2-dependent responses was observed in murine-ligated loops. The majority of GROα transcripts localized to bovine intestinal epithelium. Thus, different disease outcomes between mice (i.e., no diarrhea) and calves (i.e., diarrhea) may be due to differences in sipA sopABDE2-dependent CXC chemokine gene expression in epithelial cells.

Documentos Relacionados

• Salmonella enterica Serotype Typhimurium and Its Host-Adapted Variants
• Absence of All Components of the Flagellar Export and Synthesis Machinery Differentially Alters Virulence of Salmonella enterica Serovar Typhimurium in Models of Typhoid Fever, Survival in Macrophages, Tissue Culture Invasiveness, and Calf Enterocolitis
• Arthropod- and host-specific gene expression by Borrelia burgdorferi.
• Identification of Bradyrhizobium nod genes involved in host-specific nodulation.
• Host-specific fimbrial adhesins of noninvasive enterotoxigenic Escherichia coli strains.