Secondary Structure of the Cyclic Moiety of the Peptide Hormone Oxytocin and Its Deamino Analog*

AUTOR(ES)

Urry, D. W.

RESUMO

The secondary structure of the cyclic moiety of oxytocin and deamino-oxytocin has been determined by nuclear magnetic resonance spectroscopy (220 MHz). Oxytocin, in a dimethylsulfoxide-methanol mixture, contains a β-turn involving the sequence -L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-. Deamino-oxytocin, in addition to the β-turn, contains a hydrogen bond involving the amide hydrogen of the tyrosine residue and the peptide carbonyl group of the asparagine residue, resulting in an antiparallel β-type conformation for the ring component. An initial attempt has been made to relate conformational features of the hormonal peptides to their biological activity.

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