Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue fever

AUTOR(ES)

Vasconcelos, Jackson Nunes e, Santiago, Gilvandete Maria Pinheiro, Lima, Jefferson Queiroz, Mafezoli, Jair, Lemos, Telma Leda Gomes de, Silva, Francisca Renata Lopes da, Lima, Mary Anne Sousa, Pimenta, Antônia Torres Ávila, Braz-Filho, Raimundo, Arriaga, Angela Martha Campos, Cesarin-Sobrinho, Dari

FONTE

Química Nova

DATA DE PUBLICAÇÃO

2012

RESUMO

In the search for new larvicides from plants, we have investigated the potential activity of the rotenoids deguelin (1), 12a-hydroxy-α-toxicarol (2) and tephrosin (3), isolated from the bioactive ethanol extract of roots of Tephrosia toxicaria Pers., against Aedes aegypti, the main vector of dengue. The absolute configuration of these compounds was determined by circular dichroism (CD) spectra. The LC50 values of the compounds evaluated justify the potential of T. toxicaria as a new natural larvicide.

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