Role of Typhoid Antigens in Protection and Pathogenicity for Mice
AUTOR(ES)
Diena, B. B.
RESUMO
Swiss white mice immunized with acetone-killed vaccines prepared from strains of Salmonella typhosa, S. typhimurium, and mouse-virulent S. typhimurium hybrids which had acquired, by conjugal genetic transfer, the S. typhosa antigens 9, Vi, and d were challenged with the S. typhimurium hybrids and with the S. typhimurium parent strain. The results of these experiments suggested that the Salmonella somatic antigens were important in conferring protection against death in this system. The S. typhosa Vi antigen did not appear to play any significant role in this protection. The S. typhimurium hybrids employed in these studies did not show any loss of mouse virulence as the consequence of acquisition of various combinations of the S. typhosa somatic, flagella, or Vi antigens, nor did S. typhosa hybrids which had acquired the somatic antigen of S. typhimurium show any increase in mouse virulence.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=414939Documentos Relacionados
- Role of iron, capsule, and toxins in the pathogenicity of Vibrio vulnificus biotype 2 for mice.
- Immunity to Staphylococcal Infection in Mice: Effect of Living Versus Killed Vaccine, Role of Circulating Antibody, and Induction of Protection-Inducing Antigen(s) In Vitro
- Protection Against Meningococcal Challenge Afforded Mice After Immunization with Typhoid-Paratyphoid Vaccine USP
- BASIS FOR IMMUNITY TO TYPHOID IN MICE AND THE QUESTION OF „CELLULAR IMMUNITY”
- Pathogenicity of Yersinia kristensenii for mice.