Role of polymorphs in inflammatory cartilage destruction in adjuvant arthritis of rats.
AUTOR(ES)
Mohr, W
RESUMO
The inflammatory destruction of cartilage in rat adjuvant arthritis has been studied by histochemistry and autoradiography. Naphthol-AS-D-chloroacetate esterase has been used as a marker for polymorphs. The evidence presented here shows that polymorphs accumulate at the cartilage-pannus border and in areas of cartilage loss. These cells appear therefore to be of decisive importance for the destruction of cartilage. Proteoglycans were demonstrated by safranin-O staining: there is a loss of PG that is particularly prominent in zones where pannus had invaded cartilage. By means of 35S labelling of proteoglycans it was possible to show that pannus containing polymorphs can invade living cartilage.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1000701Documentos Relacionados
- Autoimmunity to collagen in adjuvant arthritis of rats.
- Adjuvant-induced arthritis in the temporomandibular joint of rats.
- Effect of iron complexes on adjuvant arthritis in rats.
- Role of Lymph Nodes in Adjuvant-Induced Arthritis in Rats
- Role of the thymus in induction and transfer of vaccination against adjuvant arthritis with a T lymphocyte line in rats.