Role of Lipopolysaccharide Sialylation in Serum Resistance of Serogroup B and C Meningococcal Disease Isolates

AUTOR(ES)
FONTE

American Society for Microbiology

RESUMO

α-2,3-Sialyltransferase mutants of three genetically and phenotypically diverse Neisseria meningitidis strains were compared with regard to resistance to human serum and systemic spread in the infant rat. Lipopolysaccharide sialylation was found to be of minor importance for the resistance of serogroup B and C meningococcal disease isolates to complement attack.

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