Role of Hemopoietic Colony-Forming Cell Responses in the Pathogenesis of Ectromelia
AUTOR(ES)
McNeill, T. A.
RESUMO
Intraperitoneal injection of complete Freund's adjuvant which caused an extensive cellular response in the reticuloendothelial system greatly increased the severity of infection which resulted from footpad inoculation of ectromelia virus in mice. The mortality was greatest during the proliferative phase of the cellular response, indicated by the colony-forming cell response. Exposure of colony-forming cells to virus in vitro showed that those from normal bone marrow were much less susceptible to virus than those from the bone marrow of adjuvant-treated mice and more particularly those from the spleen of adjuvant-treated mice. Severe bleeding to induce anemia and a consequent erythropoietic response did not increase the mortality from ectromelia. Previous results were interpreted on the basis of these findings and a more general application of them to the pathogenesis of poxvirus infection was discussed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=416310Documentos Relacionados
- Hemopoietic Colony-Forming Cell Responses in Mice Infected with Ectromelia Virus
- Responses of the Murine Myeloid Colony-Forming Cell to Ansamycin Antibiotics
- Hemopoietic colony-forming cells in umbilical cord blood with extensive capability to generate mono- and multipotential hemopoietic progenitors.
- Identification in culture of a class of hemopoietic colony-forming units with extensive capability to self-renew and generate multipotential hemopoietic colonies.
- Segregation of keratinocyte colony-forming cells in the bulge of the rat vibrissa.