Role of gastrin supersensitivity in the pathogenesis of lower esophageal sphincter hypertension in achalasia

AUTOR(ES)

Cohen, Sidney

RESUMO

Intraluminal manometric studies were carried out in 19 patients with untreated achalasia and in 20 normals. Lower esophageal sphincter (LES) pressure was 50.5 ±4.6 mm Hg in patients with achalasia as compared with 19.4 ±1.3 mm Hg in the normal group. In both groups, the LES pressure was lowered when exogenous 0.1 N HCl was placed into the stomach. Although the nadir of pressure attained with acid suppression was the same, the per cent inhibition was significantly greater in patients with achalasia. Serum gastrin levels were the same in the two groups studied. The patients with achalasia, pre- and postpneumatic dilatation, showed a supersensitivity to exogenous intravenous gastrin I, as compared with normals. These data suggest that high, acid-suppressible levels of LES pressure, in patients with achalasia, are due to supersensitivity to endogenous gastrin.

Documentos Relacionados

• The Adrenergic Control of Lower Esophageal Sphincter Function: AN EXPERIMENTAL MODEL OF DENERVATION SUPERSENSITIVITY
• The Genesis of Lower Esophageal Sphincter Pressure: Its Identification through the Use of Gastrin Antiserum
• Hormonal regulation of human lower esophageal sphincter competence: interaction of gastrin and secretin
• Mechanics of Sphincter Action. STUDIES ON THE LOWER ESOPHAGEAL SPHINCTER
• Pharmacologic identification of the lower esophageal sphincter