Role of Gamma Interferon and Interleukin-4 in Host Defense against the Human Filarial Parasite Brugia malayi

AUTOR(ES)

Babu, Subash

FONTE

American Society for Microbiology

RESUMO

We have investigated the roles of gamma interferon (IFN-γ) and interleukin-4 (IL-4) in host defense against Brugia malayi. Our data suggest that the lack of either IFN-γ or IL-4 prolongs the time required to achieve sterile immunity, suggesting that both canonical type 1 and type 2 responses are involved in the clearance of infection.

Documentos Relacionados

• Role of nitric oxide in host defense against an extracellular, metazoan parasite, Brugia malayi.
• Cloning and comparison of repeated DNA sequences from the human filarial parasite Brugia malayi and the animal parasite Brugia pahangi.
• T Cells Are Required for Host Protection against Brugia malayi but Need Not Produce or Respond to Interleukin-4
• Characteristics of Invasive Candidiasis in Gamma Interferon- and Interleukin-4-Deficient Mice: Role of Macrophages in Host Defense against Candida albicans
• Roles of interferon-gamma and interleukin-4 in murine lupus.