Risk factors associated with diabetes after liver transplant
AUTOR(ES)
Campos, Mariana Baldini; Riguetto, Cínthia Minatel; Boin, Ilka de Fátima Santana Ferreira; Moura Neto, Arnaldo
FONTE
Archives of Endocrinology and Metabolism
DATA DE PUBLICAÇÃO
2022
RESUMO
ABSTRACT Objective: Post-transplant diabetes mellitus (PTDM) is a common metabolic complication after liver transplant that negatively affects a recipient's survival and graft function. This study aims to identify risk factors associated with diabetes after liver transplant. Materials and methods: This is a cross-sectional study conducted from September to November 2019. Data collection was performed by chart review, and patients were divided into 3 groups: patients without diabetes mellitus (DM), patients with pre-transplant diabetes mellitus, and patients with PTDM. Results: Two hundred and forty-seven patients’ medical charts were screened, and 207 patients were included: 107 without DM, 42 with pre-transplant DM, and 58 with PTDM. The leading cause for liver transplant was hepatitis C, followed by hepatocellular carcinoma secondary to alcohol. There was a higher exposure to tacrolimus in patients without DM ( P = 0.02) and to ciclosporin in patients with pre-transplant DM, compared to others ( P = 0.005). Microscopic interface inflammatory activity was more severe in patients without DM as well as those with PTDM ( P = 0.032). There was a higher prevalence of steatosis in recipients with pre-transplant DM than there was in others ( P < 0.001). Multivariate logistic regression identified the following independent risk factors for DM: cirrhosis due to alcohol, hepatitis C, and triglycerides. For PTDM, these independent risk factors were cirrhosis due to alcohol, hepatitis C, and prednisone exposure. Conclusion: Alcoholic cirrhosis is a risk factor for PTDM in liver recipients. Liver transplant recipients with a pre-transplant history of cirrhosis due to alcohol, hepatitis C, and prednisone exposure deserve more caution during PTDM screening.
Documentos Relacionados
- Hepatitis E seroprevalence and associated risk factors in Croatian liver transplant recipients
- Risk factors associated with nonalcoholic fatty liver disease evaluated by elastography in patients with type 2 diabetes
- Factors associated with the development of candidemia and candidemia-related death among liver transplant recipients.
- Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus
- Study of factors affecting the incidence of skin cancer in patients after liver transplant