Ribosomal Vaccines I. Immunogenicity of Ribosomal Fractions Isolated from Salmonella typhimurium and Yersinia pestis
AUTOR(ES)
Johnson, William
RESUMO
The immunogenicity of ribosomes and ribosomal subfractions isolated from Yersina pestis and Salmonella typhimurium has been studied. Ribosomes and ribosomal protein isolated from S. typhimurium protected mice against lethal challenge. Ribosomal ribonucleic acid isolated by phenol extraction failed to induce any significant level of protection in mice. None of the ribosomes or ribosomal subfractions isolated from Y. pestis were effective in inducing immunity to lethal challenge. These results suggest that the immunogen of the ribosomal vaccine is protein.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=422469Documentos Relacionados
- Ribosomal Vaccines II. Specificity of the Immune Response to Ribosomal Ribonucleic Acid and Protein Isolated from Salmonella typhimurium
- Immunogenicity of Ribosomal Vaccines Isolated from Group A, Type 14 Streptococcus pyogenes
- Identification of protective cell surface proteins in ribosomal fractions from Salmonella typhimurium.
- Temperature-modulated immunogenicity to Yersinia pestis from Yersinia enterocolitica O3.
- Evidence for an extrinsic immunogen in effective ribosomal vaccines from Salmonella typhimurium.