Ribosomal suppressors and antisuppressors in Podospora anserina: resistance to cycloheximide.
AUTOR(ES)
Coppin-Raynal, E
RESUMO
Informational suppressors and antisuppressors have been previously isolated in Podospora anserina, and a range of exclusively genetic arguments have led to the assumption that they correspond to ribosomal mutations. An in vivo and in vitro comparison of the effect of the ribosomal inhibitor cycloheximide on wildtype and mutant strains described in this paper confirms the ribosomal hypothesis for at least some mutants. Indeed, the four mutants in the AS3 gene were cycloheximide resistant, and their ribosomes were found to be resistant when analyzed by polyuridyl-directed polyphenylalanine systhesis. On the other hand, ribosomes from two su 1 mutants were hypersensitive to the drug.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=235544Documentos Relacionados
- Protoplasmic Incompatibility in PODOSPORA ANSERINA: a Possible Function for Incompatibility Genes
- Protoplasmic Incompatibility in PODOSPORA ANSERINA: A Possible Role for Its Associated Proteolytic Activity
- Incompatibility in Podospora anserina: Comparative Properties of the Antagonistic Cytoplasmic Factors of a Nonallelic System
- Premature Death in Podospora Anserina: Sporadic Accumulation of the Deleted Mitochondrial Genome, Translational Parameters and Innocuity of the Mating Types
- Nonintegrative transformation in the filamentous fungus Podospora anserina: stabilization of a linear vector by the chromosomal ends of Tetrahymena thermophila.
