Retroelements and the human genome: New perspectives on an old relation

AUTOR(ES)

Bannert, Norbert

FONTE

National Academy of Sciences

RESUMO

Retroelements constitute a large portion of our genomes. One class of these elements, the human endogenous retroviruses (HERVs), is comprised of remnants of ancient exogenous retroviruses that have gained access to the germ line. After integration, most proviruses have been the subject of numerous amplifications and have suffered extensive deletions and mutations. Nevertheless, HERV-derived transcripts and proteins have been detected in healthy and diseased human tissues, and HERV-K, the youngest, most conserved family, is able to form virus-like particles. Although it is generally accepted that the integration of retroelements can cause significant harm by disrupting or disregulating essential genes, the role of HERV expression in the etiology of malignancies and autoimmune and neurologic diseases remains controversial. In recent years, striking evidence has accumulated indicating that some proviral sequences and HERV proteins might even serve the needs of the host and are therefore under positive selection. The remarkable progress in the analysis of host genomes has brought to light the significant impact of HERVs and other retroelements on genetic variation, genome evolution, and gene regulation.

Documentos Relacionados

• An old enemy, a new battle plan: Perspectives on combating drug-resistant malaria
• Visualizing the genome: techniques for presenting human genome data and annotations
• LINE dancing in the human genome: transposable elements and disease
• Human Cytomegalovirus Genome: Partial Denaturation Map and Organization of Genome Sequences
• Microsatellite spreading in the human genome: evolutionary mechanisms and structural implications.