Restrição proteica e estresse oxidativo em ratos submetidos ou não ao exercicio fisico

AUTOR(ES)

Francisco Jose Andriotti Prada

DATA DE PUBLICAÇÃO

2005

RESUMO

Malnourished human beings and animais show impaired function in several organs, which is not a fully reversed by nutritional recovery. Physical training, in turn, accelerates some aspects of nutritional recovery. There are few data on the participation of oxidative stress in the functional impairment imposed by malnutrition. The literatura locks information on the effects of physical training associated to nutritional recovery on oxidative stress. The present study was designed to evaluate the balance between oxidative attack and antioxidant mechanisms in young rats submitted to alimentary pratein restriction and recovered with balanced diet associated or not to aerobic physical training (swimming and running). The main oxidative damage biomarkers was the blood thiobarbituric acid reactive substances amount (TBARs) and reactive carbonyl derivatives (RCD) amounts while the antioxidant system biomarkers were the blood catalase (CAT) and glutathione reductase (GR) activities. Pratein deficient animais showed increase the in oxidative damage (TBARs) in relation to controls that induced an increase in antioxidant enzymes activity (CAT and GR). Physical training increased oxidative damage (TBARs) and reduced antioxidant defense (CAT and GR) in control animais. Physical training during nutritional recovery accelerated body growth (weight gain) of pratein restricted rats without increasing oxidative damage (TBARs). Both swim and run training reduced CA T activity during nutritional recovery. Swim training reduced also GR activity. In summary, taken together these results suggest that the improvement in body growth during nutritional recovery associated to physical training may be related, at least in part to a decrease in the oxidative stress levels

ASSUNTO(S)

recuperação nutricional estresse oxidativo desnutrição proteica exercico fisico

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