Resposta imune autoreativa aos componentes da mielina em pacientes portadores da forma gastrointestinal da doença de Chagas

AUTOR(ES)
DATA DE PUBLICAÇÃO

2004

RESUMO

Most reports of autoimmune response during infection with the parasite Trypanosoma cruzi have dealt with the cardiomyopathic forro of Chagas disease, but there is another, less common, gastrointestinal forro, which is studied here. Chronically infected patients with a severe gastrointestinal forro of Chagas disease present increased antibody production and proliferative responses to peripheral myelin components, such as myelin basic protein and peripheral nerve structures. T lymphocytes preferentially recognize a region on the myelin basic protein (MBP) molecule (1-30), which suggests that the MBP is a potential target on the peripheral nerve for autoimmune reactions in patients with gastrointestinallesions resulting ITomChagas disease

ASSUNTO(S)

chagas antigenos parasitarios doença de tripanossoma cruzi

Documentos Relacionados