Resistance and susceptibility of mice to bacterial infection: course of listeriosis in resistant or susceptible mice.

AUTOR(ES)

Cheers, C

RESUMO

Resistance and susceptibility to Listeria monocytogenes in mice was found to be related to (i) the innate ability of the nonimmune macrophages to kill or inhibit the growth of the organism during the first 24 to 48 h after infection, and (ii) the time of onset of acquired cell-mediated resistance. Resistant C57Bl/6 mice were 10 times more efficient than susceptible BALB/c mice at suppressing the early growth of Listeria in the liver. Furthermore, the onset of acquired immunity occurred 24 to 48 h earlier in C57Bl/6 than in BALB/c mice. Acquired immunity was measured by (i) fall in bacterial numbers in spleen and livers of infected mice (ii) adoptive transfer of immunity to normal mice by using spleen cells from infected mice, (iii) delayed-type hypersensitivity skin testing, and (iv) uptake of tritiated thymidine by lymphocytes in the spleen.

Documentos Relacionados

• Resistance and Susceptibility of Mice to Bacterial Infection: Histopathology of Listeriosis in Resistant and Susceptible Strains
• Resistance and susceptibility of mice to bacterial infection: genetics of listeriosis.
• Resistance and Susceptibility of Mice to Bacterial Infection: Genetics of Listeriosis
• Susceptibility of inbred mice to Leishmania major infection: genetic analysis of macrophage activation and innate resistance to disease in individual progeny of P/J (susceptible) and C3H/HeN (resistant) mice.
• Memory T cell-mediated resistance to Mycobacterium tuberculosis infection in innately susceptible and resistant mice.