Residual C-peptide in patients with Type 1 diabetes and multiethnic backgrounds

AUTOR(ES)

Almeida, Mirella Hansen de, Dantas, Joana Rodrigues, Barone, Bianca, Serfaty, Fabiano Marcel, Kupfer, Rosane, Albernaz, Marta, Bencke, Maria Rocio, Zajdenverg, Lenita, Rodacki, Melanie, Oliveira, José Egídio Paulo de

FONTE

Clinics

DATA DE PUBLICAÇÃO

2013-01

RESUMO

OBJECTIVE: To evaluate serum C-peptide in 88 patients from a multiethnic population with Type-1 diabetes and variable disease durations. METHOD: Eighty-eight patients with a mean disease duration of 8.1 +7.6 years were included and underwent C-peptide measurement before and after glucagon stimulation. Chi-squared and Mann Whitney U-tests were used to compare the variables between groups (all two-tailed, a = 0.05). Spearmans correlation coefficient was used to test the association between the continuous variables. Logistic regression was used for the multivariate analysis. Twenty-eight (31.8%) individuals had significantly detectable C-peptide levels after stimuli, particularly those with a shorter disease duration (p<0.001). RESULTS: Patients with detectable C-peptide levels required lower insulin doses (p<0.009) and had similar HbA1C results (p = 0.182) and fewer chronic complications (p = 0.029). CONCLUSION: C-peptide detection was common in Type-1 diabetics, particularly shortly after being diagnosed. This result may have clinical implications.

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