Requirement for CD40 Ligand, CD4+ T Cells, and B Cells in an Infectious Mononucleosis-Like Syndrome

AUTOR(ES)

Brooks, James W.

FONTE

American Society for Microbiology

RESUMO

Respiratory challenge with the murine gammaherpesvirus 68 (γHV-68) results in productive infection of the lung, the establishment of latency in B lymphocytes and other cell types, transient splenomegaly, and prolonged clonal expansion of activated CD8+ CD62Llo T cells, particularly a Vβ4+ CD8+ population that is found in mice with different major histocompatibility complex (MHC) haplotypes. Aspects of the CD8+-T-cell response are substantially modified in mice that lack B cells, CD4+ T cells, or the CD40 ligand (CD40L). The B-cell-deficient mice show no increase in Vβ4+ CD8+ T cells. Similar abrogation of the Vβ4+ CD8+ response is seen following antibody-mediated depletion of the CD4+ subset, through the numbers of CD8+ CD62Llo cells are still significantly elevated. Virus-specific CD4+-T-cell frequencies are minimal in the CD40L−/− mice, and the Vβ4+ CD8+ population remains unexpanded. Apparently B-cell–CD4+-T-cell interactions play a part in the γHV-68 induction of both splenomegaly and non-MHC-restricted Vβ4+ CD8+-T-cell expansion.

Documentos Relacionados

• Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40–CD40 ligand signaling in atherosclerosis
• Increased interleukin 12 production in progressive multiple sclerosis: Induction by activated CD4+ T cells via CD40 ligand
• Distinct Cytokine Regulation by Cholera Toxin and Type II Heat-Labile Toxins Involves Differential Regulation of CD40 Ligand on CD4+ T Cells
• Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection
• Functional CD40 ligand is expressed by T cells in rheumatoid arthritis.