Relationship of the Structure of Bacterial Lipopolysaccharides to Its Function in Mitogenesis and Adjuvanticity
AUTOR(ES)
Chiller, Jacques M.
RESUMO
The ability of bacterial lipopolysaccharides to induce lymphocyte mitogenesis and to act as an adjuvant of antibody formation was attributable to the lipid-A region of the molecule. Measured by induction of DNA synthesis, lipid A was mitogenic for bone marrow-derived lymphocytes obtained from spleens of congenitally athymic mice but not for thymocytes obtained from thymuses of normal mice. Adjuvanticity was demonstrated by the ability of lipid A to convert a tolerogenic regimen of antigen into one eliciting an immune response and by its ability to markedly enhance the antibody response to a weak antigen.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=433681Documentos Relacionados
- RELATIONSHIP OF STRUCTURE TO FUNCTION IN BACTERIAL O ANTIGENS: III. Biological Properties of Endotoxoids
- Relationship of structure to function in bacterial endotoxins. IX. Differences in the lipid moiety of endotoxic glycolipids.
- Structure of Exocellular Polymers and Their Relationship to Bacterial Flocculation
- Structure-function relationship of bacterial prolipoprotein diacylglyceryl transferase: functionally significant conserved regions.
- RENAL FUNCTION IN BURNED PATIENTS AND ITS RELATIONSHIP TO MORPHOLOGICAL CHANGES
