Relationship Between Methionyl Transfer Ribonucleic Acid Cellular Content and Synthesis of Methionine Enzymes in Saccharomyces cerevisiae
AUTOR(ES)
Surdin-Kerjan, Y.
RESUMO
Derepression of some methionine biosynthetic enzymes (methionine group I enzymes) obtained in methionine limitation has been found to be accompanied by a significant lack of in vivo charging of bulk methionine transfer ribonucleic acid (tRNAMet) and in addition by a decreased rate of synthesis of all tRNAs. Under the same conditions, methionyl-tRNA synthetase (MTS) was derepressed rather than repressed. These results are in agreement with those previously published based on studies of a mutant with an impaired MTS (5) and reinforce the idea that the rate of synthesis of methionine group I enzymes can be related to the total content of methionyl (Met)-tRNA Met per cell. They also render unlikely that MTS could be a constituent of the regulatory signal.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=251676Documentos Relacionados
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