Relation of parental age to rigidity in Huntington's disease

AUTOR(ES)

Brackenridge, C. J.

RESUMO

The birth ranks and parental ages at birth of subjects affected with Huntington's disease were ascertained from the literature and examined in relation to the neurological sign displayed (muscular rigidity or choreo-athetosis). With respect to the sex of the affected parent, the percentage of rigid cases was found to decrease linearly with advancing paternal age and to increase linearly with advancing maternal age. In contrast, no significant relation was found for birth rank or for age of the unaffected parent.

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